Acute endothelin a receptor blockade in heart failure.
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چکیده
tables or figures and should relate solely to an article published in Circulation within the preceding 12 weeks. Authors of letters selected for publication will receive prepublication proofs, and authors of the article cited in the letter will be invited to reply. Replies must be signed by all authors listed in the original publication. Please submit three typewritten, double-spaced copies of the letter to Herbert L. Fred, MD, 0 the Circulation Editorial Office. Letters will not be returned.
منابع مشابه
Effect of Endothelin-A Receptor Blockade on the Early Phase of Ischemia/Reperfusion-Induced Acute Renal Failure in Anesthetized Rats
Background: Previous studies have shown increases in endothelin (ET) concentration of plasma and renal tissues in acute renal failure (ARF). ET has a potent vasoconstrictor effect, through binding with its ETA receptors, and may play some roles in renal hemodynamic dysfunction in ARF.Objective: To examine the beneficial effect of a selective ETA-receptor antagonist on renal dysfunction and tis...
متن کاملEndothelin receptor blockade and exacerbation of heart failure.
of Heart Failure To the Editor: We have read with interest the report by Lüscher et al1 on the Heart Failure Endothelin A Receptor Blockade Trial (HEAT). Administration of an endothelin A receptor antagonist, darusentan (30, 100, or 300 mg/d), for 3 weeks significantly decreased systemic vascular resistance with concomitant increase in cardiac index in patients with chronic heart failure (HF). ...
متن کاملEndothelin-A/Endothelin-B Receptor Blockade in Rat Chronic Heart Failure
Paul Mulder, Houssaine Boujedaini, Vincent Richard, Genevieve Derumeaux, Jean Paul Henry, in Rat Chronic Heart Failure Selective Endothelin-A Versus Combined Endothelin-A/Endothelin-B Receptor Blockade Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas...
متن کاملSelective endothelin-A versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure.
BACKGROUND The relative efficacy of endothelin-A (ET(A)) receptor blockade versus combined ET(A)-ET(B) receptor blockade in chronic heart failure (CHF) is still largely unknown. METHODS AND RESULTS We compared, in a rat model of CHF (coronary ligation), the hemodynamic and structural effects of 1 month of treatment with the ET(A) antagonist ABT-627 (5 mg x kg(-1) x d(-1)), the ET(B) antagonis...
متن کاملEndothelin receptor blockade has an oxygen-saving effect in Dahl salt-sensitive rats with heart failure.
The effects of endothelin (ET) receptor blockade on energy utilization in heart failure (HF) are unknown. We administered ET type A (ETA), ET type B (ETB), and ETA/ETB antagonists to isolated hearts from Dahl salt-sensitive (DS) rats with HF and controls. Contractile efficiency was assessed as slope-1 of myocardial O consumption (VO2)-pressure-volume area relation. In HF, ETA and ETA/ETB but no...
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عنوان ژورنال:
- Circulation
دوره 103 18 شماره
صفحات -
تاریخ انتشار 2001